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pharmaceutical intermediate - Acetophenone

pharmaceutical intermediate - Acetophenone
Product Detailed
pharmaceutical intermediate - Acetophenone 99%min Long history of manufacturing Advanced formula Great cost performance

pharmaceutical intermediate - Acetophenone

Chemical formula:C8H8O

Molecular weight:120.15

CAS No.:98-86-2

Speficication:

ItemValue
Density1.0266
Melting point19.6°C
Boiling point202°C
Refractive index1.5315-1.534
Flash point77°C
Water solubility5.5g/l(20°C)

Usage:

Use in pharmaceutical and related areas

Acetophenone is a raw material for the synthesis of some pharmaceuticals and is also listed as an approved excipient by the U.S. FDA. In a 1994 report released by five top cigarette companies in the U.S., acetophenone was listed as one of the 599 additives to cigarettes.

Precursor to resins

Commercially significant resins are produced from treatment of acetophenone with and base. The resulting polymers are conventionally described with the formula [(C6H5C(O)CH]x(CH2)x}n, resulting from . These materials are components of and . Modified acetophenone-formaldehyde resins are produced by the hydrogenation of the aforementioned ketone-containing resins. The resulting can be further crosslinked with . These modified resins are again found in coatings, inks, as well as .

Precursor to styrene

In instructional laboratories, acetophenone is converted to in a two step process that illustrates the reduction of carbonyls and the dehydration of alcohols:

4 C6H5C(O)CH3 + + 4 H2O → 4 C6H5CH(OH)CH3 + NaOH + B(OH)3

A similar process is used industrially but the hydrogenation step to 1-phenylethanol is done over a copper catalyst.

C6H5CH(OH)CH3 → C6H5CH=CH2 + H2O 

 

Package:

Packed in plastic or steel drum, net weight 200kg/drum.

pharmaceutical intermediate - Acetophenone



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